SCF technologies for chromatography and micronization of drugs

Abstract

We demonstrate applicability of supercritical fluid (SCF) chromatography for the chiral separation of the substance of salbutamol sulfate (SS) racemic mixture and for production of the solutions with concentration of the active R-isomer greater than 98%. We have developed a SCF chromatography method for simultaneous qualitative determination of vitamins A and E in a mixture, which can be recommended for industrial implementation. We have also developed a method for SS micronization based on Supercritical AntiSolvent precipitation method (SAS). We were able to produce nearly spherical particles. Finally, we propose an optimization of conditions for production of micronized particles, which can be used for development of laboratory procedures for production of micronized substance.